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Currently, the role of myosteatosis, insulin resistance, and inflammation on age-related muscle anabolic resistance is unclear and warrants further investigation. Therefore, the aim of the current study was to comprehensively assess the physical activity, whole-body/muscle metabolic health, and inflammatory characteristics of (1) young lean (YL), (2) older lean (OL), and (3) older obese (OO) individuals to establish whether, and to what extent, these parameters were associated with MyoPS in the postabsorptive state and in response to moderate-dose protein provision. We hypothesized that postprandial MyoPS rates would be impaired in OL, but more so in OO individuals compared with YL individuals and would therefore be closely associated with levels of physical activity, adiposity, and inflammatory markers. Ten OL and 10 OO individuals were recruited for comparison against 18 YL individuals ( Table 1 ). Participants completed a general health questionnaire and were excluded from participating if they had type 2 diabetes, uncontrolled hypertension, neuromuscular/cardiovascular/metabolic disease, or if they were smokers, losing weight, or taking nonsteroidal anti-inflammatory drugs, legit kit quilt.
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